company news about Ready-to-Use (RTU) Pharmaceutical Glass Vials

Ready-to-Use (RTU) Pharmaceutical Glass Vials

    Ready-to-use vials can be filled immediately without further processing.This requires the vials to be cleaned to remove particles, to remove depyrogenated, to remove endotoxins, and to perform terminal sterilization.The vials are often supplied with appropriate stoppers and caps to close the vial post filling.

    –Washing. This process is undertaken normally with an automated washer. The washer will spray the vials internally and externally with pressurised, injection quality water water.

    – Depyrogenation. This process is undertaken using a heated oven and has an objective to remove endotoxins from the vials. A typical cycle is to heat the vials for 250°C for at least 30 minutes.

    –Terminal Sterilisation. The vials are packed in RFQ bags and PP inner boxes. The packing process is undertaken within a cleanroom (ISO Class 4.8) to avoid contamination of the vials. The vials are then sterilized with ethylene oxide. The final RTU packed glass vials can be stored for up to 5 years before use depending on the sterile barrier packaging used.